Find Portland

Friday, October 14, 2016

Adipost

Generic Name: phendimetrazine (fen di MEH tra zeen)

Brand Names: Adipost, Bontril PDM, Bontril Slow Release, Melfiat

What is Adipost (phendimetrazine)?

Phendimetrazine is similar to an amphetamine. Phendimetrazine stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.

Phendimetrazine is used as a short-term supplement to diet and exercise in the treatment of obesity.

Phendimetrazine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Adipost (phendimetrazine)?

Phendimetrazine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Phendimetrazine may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it. Do not stop using phendimetrazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using phendimetrazine. Do not crush, chew, break, or open the extended-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

What should I discuss with my healthcare provider before taking Adipost (phendimetrazine)?

Do not use phendimetrazine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you are allergic to phendimetrazine, or if you have:

coronary artery disease (hardening of the arteries);

heart disease;

severe or uncontrolled high blood pressure;

heart murmur or heart valve disorder;

pulmonary arterial hypertension (PAH);

overactive thyroid;

glaucoma;

severe agitation or nervousness;

if you have a history of drug or alcohol abuse; or

if you are allergic to other diet pills, amphetamines, stimulants, or cold medications.

To make sure you can safely take phendimetrazine, tell your doctor if you have any of these other conditions:

high blood pressure;

diabetes;

an anxiety disorder;

epilepsy or seizure disorder; or

if you have used other diet pills in the past year (prescription, over-the-counter, or herbal products).

It is not known whether phendimetrazine will harm an unborn baby. Do not take phendimetrazine without first talking to your doctor if you are pregnant. It is also not known whether phendimetrazine passes into breast milk. Do not take phendimetrazine without first talking to your doctor if you are breast-feeding a baby.

How should I take Adipost (phendimetrazine)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Phendimetrazine should be taken only for a short time, such as a few weeks.

Phendimetrazine is usually taken once daily. Follow your doctor's instructions.

Take phendimetrazine on an empty stomach, 30 to 60 minutes before your morning meal. Do not crush, chew, break, or open the extended-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time. You should lose at least 4 pounds during the first 4 weeks of taking phendimetrazine and eating a low calorie diet. Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks. Do not stop using phendimetrazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using phendimetrazine. Never take more of this medication than is prescribed for you. Too much phendimetrazine could be very dangerous to your health. Talk with your doctor if you have increased hunger or if you otherwise think the medication is not working properly. Taking more of this medication will not make it more effective and can cause serious, life-threatening side effects. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

A dose taken too late in the day will cause insomnia.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of phendimetrazine can be fatal.

Overdose symptoms of a phendimetrazine overdose include nausea, vomiting, diarrhea, stomach cramps, confusion, panic, hallucinations, extreme restlessness, feeling tired or depressed, ringing in your ears, chest pain, slow heart rate, weak pulse, fainting, seizure, or slow breathing (breathing may stop).

What should I avoid while taking Adipost (phendimetrazine)?

Phendimetrazine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Adipost (phendimetrazine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using phendimetrazine and call your doctor at once if you have a serious side effect such as:

feeling short of breath, even with mild exertion;

chest pain, feeling like you might pass out;

swelling in your ankles or feet;

pounding heartbeats or fluttering in your chest;

confusion or irritability, unusual thoughts or behavior;

feelings of extreme happiness or sadness; or

dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

feeling restless or hyperactive;

headache, dizziness, tremors;

sleep problems (insomnia);

flushing (warmth, redness, or tingly feeling);

dry mouth;

diarrhea or constipation, upset stomach; or

increased or decreased interest in sex, impotence.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Adipost (phendimetrazine)?

Tell your doctor about all other medicines you use, especially:

insulin; or

any other diet pills.

This list is not complete and other drugs may interact with phendimetrazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Adipost resources

Adipost Side Effects (in more detail)
Adipost Use in Pregnancy & Breastfeeding
Adipost Drug Interactions
Adipost Support Group
1 Review for Adipost - Add your own review/rating

Phendimetrazine Prescribing Information (FDA)

Bontril PDM Advanced Consumer (Micromedex) - Includes Dosage Information

Bontril PDM MedFacts Consumer Leaflet (Wolters Kluwer)

Phendimetrazine Tartrate Monograph (AHFS DI)

Compare Adipost with other medications

Obesity

Where can I get more information?

Your pharmacist can provide more information about phendimetrazine.

See also: Adipost side effects (in more detail)

Abatacept

Class: Disease-modifying Antirheumatic Agents
Chemical Name: Fusion protein with an extracellular domain of human cytotoxic T-lymphocyte-associated antigen (CTLA-4) and modified Fc domain of human immunoglobulin G1
Molecular Formula: C₁₉₆₅H₃₀₈₀N₄₇₉O₆₉₅S₁₆
CAS Number: 332348-12-6
Brands: Orencia

Introduction

Biologic response modifier and disease-modifying antirheumatic drug (DMARD); a recombinant fusion protein.¹ ² ³ ⁴ ⁵

Uses for Abatacept

Rheumatoid Arthritis

Used to manage the signs and symptoms of rheumatoid arthritis, to induce a major clinical response, to improve physical function, and to inhibit progression of structural damage associated with the disease in adults with moderate to severe active rheumatoid arthritis.¹ ² ³ ⁴ ⁵ Can be used alone or with other DMARDs other than tumor necrosis factor (TNF) blocking agents.¹

Do not use concomitantly with TNF blocking agents (e.g., adalimumab, certolizumab pegol, etanercept, infliximab); concomitant use with other biologic antirheumatic drugs (e.g., anakinra) not recommended.¹ (See Infectious Complications under Cautions and see Specific Drugs and Laboratory Tests under Interactions.)

Juvenile Arthritis

Management of the signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in children.¹ ⁷ Can be use alone or with methotrexate.¹

Abatacept Dosage and Administration

Administration

IV Administration

For solution and drug compatibility information, see Compatibility under Stability.¹

Administer by IV infusion.¹

Administer with an in-line, sterile, nonpyrogenic, low-protein-binding filter with a pore diameter ≤1.2 mcm.¹

Consult manufacturer’s labeling for additional information on reconstitution, dilution, and administration.¹

Reconstitution

Reconstitute the appropriate number of vials containing 250 mg of abatacept lyophilized powder with 10 mL of sterile water for injection to provide a solution containing 25 mg/mL.¹

Use only the silicone-free disposable syringe provided by the manufacturer and an 18–21 gauge needle.¹ If a siliconized syringe is inadvertently used, translucent particles may develop and solution should be discarded.¹

Direct sterile water for injection toward the side of the vial during reconstitution; swirl gently to minimize foaming.¹ Do not shake.¹ Upon dissolution, insert a vented needle into the vial to dissipate foam.¹ Must be diluted further before IV administration.¹

Dilution

Remove the volume of diluent equal to the total required volume of reconstituted abatacept solution from a 100 mL bag of 0.9% sodium chloride injection.¹

Using same silicone-free disposable syringe used for reconstitution, slowly add reconstituted abatacept to the bag to a total volume of 100 mL; mix gently.¹

Rate of Administration

Infuse over 30 minutes.¹

Dosage

Dosage is based on patient's weight.¹

Pediatric Patients

Juvenile Arthritis

IV

Children 6–17 years of age weighing <75 kg: 10 mg/kg at 0, 2, and 4 weeks, then every 4 weeks.¹

Children 6–17 years of age weighing ≥75 kg: Use adult dosage.¹

Adults

Rheumatoid Arthritis

IV

Adults weighing <60 kg: 500 mg at 0, 2, and 4 weeks, then every 4 weeks.¹

Adults weighing 60–100 kg: 750 mg at 0, 2, and 4 weeks, then every 4 weeks.¹

Adults weighing >100 kg: 1 g at 0, 2, and 4 weeks, then every 4 weeks.¹

Prescribing Limits

Pediatric Patients

Juvenile Arthritis

IV

Children 6–17 years of age weighing ≥75 kg: Maximum dose is 1 g.¹

Special Populations

No special population dosage recommendations at this time.¹

Cautions for Abatacept

Contraindications

None known.¹

Warnings/Precautions

Warnings

Infectious Complications

Serious infections (including pneumonia, cellulitis, urinary tract infections, bronchitis, diverticulitis, and acute pyelonephritis) reported, particularly in patients receiving concomitant TNF-blocking agents.¹

Concomitant use of abatacept and TNF-blocking agents is not recommended.¹ Monitor patients being switched from TNF-blocking agents to abatacept for infection.¹ (See Specific Drugs and Laboratory Tests under Interactions.)

Discontinue abatacept if serious infection develops.¹ Closely monitor patients who develop new infections.¹

Use caution in patients with a history of recurring infections, underlying conditions that may predispose them to infections, or chronic, latent, or localized infections.¹

Evaluate all patients for active or latent tuberculosis prior to initiation of abatacept therapy.¹ When indicated, initiate appropriate antimycobacterial regimen for the treatment of latent tuberculosis infection prior to abatacept.¹

Hepatitis B Virus (HBV) Reactivation

Use of antirheumatic drugs associated with reactivation of HBV infection in patients who are chronic carriers of the virus (i.e., hepatitis B surface antigen-positive [HBsAg-positive]).¹ Screen patients at risk prior to initiation of therapy.¹

Sensitivity Reactions

Hypersensitivity Reactions

Anaphylaxis or anaphylactoid reactions reported.¹ ⁶ Other allergic reactions (e.g., hypotension, urticaria, dyspnea) reported rarely.¹

If serious hypersensitivity reaction occurs, discontinue immediately and institute appropriate therapy as indicated (e.g., epinephrine, corticosteroids, maintenance of an adequate airway, oxygen).¹

Acute Infusion Reactions

Acute infusion reactions (e.g., dizziness, headache, hypertension, hypotension, dyspnea, nausea, flushing, urticaria, cough, pruritus, rash, wheezing) reported within 1 hour after IV infusion.¹

General Precautions

Vaccination

Vaccine efficacy may be reduced; avoid live virus vaccines during abatacept therapy or within 3 months after discontinuance of the drug.¹ (See Vaccines under Interactions and see Pediatric Use under Cautions.)

COPD

Possible exacerbations of COPD, cough, rhonchi, and dyspnea.¹

Use with caution; careful monitoring recommended for worsening of respiratory function.¹

Immunosuppression

Possibility exists for agents that inhibit T-cell activation, including abatacept, to affect host defenses against infection and malignancies.¹ (See Infectious Complications and also see Malignancies and Lymphoproliferative Disorders, under Cautions.)

Malignancies and Lymphoproliferative Disorders

Lymphoma and lung cancer reported more frequently in patients receiving abatacept versus control.¹ Rheumatoid arthritis patients, especially with highly active disease, may be at increased risk of lymphoma.¹ ⁶

Other malignancies (e.g., myelodysplastic syndrome, melanoma, breast, bile duct, bladder, cervical, endometrial, ovarian, prostate, renal, thyroid, uterine, and nonmelanoma skin cancer) also reported.¹

Role of abatacept in the development and course of malignancies not fully determined.¹ ⁶

Immunogenicity

Antibodies to abatacept may develop; not associated with decreased clinical response or increased adverse events.¹

Blood Glucose Testing

Parenteral preparations containing maltose, including abatacept injection, may cause falsely elevated results in blood glucose determinations that use glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ).¹ (See Specific Drugs and Laboratory Tests under Interactions.)

Specific Populations

Pregnancy

Category C.¹

Lactation

Distributed into milk in rats; not known whether distributed into human milk.¹ Discontinue nursing or the drug.¹

Pediatric Use

Safety and efficacy for the management of juvenile idiopathic arthritis established in pediatric patients ≥6 years of age.¹ Safety and efficacy not established in children <6 years of age; use in this age group not recommended.¹

Safety and efficacy for uses other than juvenile idiopathic arthritis not established in pediatric patients.¹

Review vaccination status of the child and administer all age-appropriate vaccines prior to initiation of abatacept.¹

Adverse effects reported in children similar to those reported in adults.¹

Geriatric Use

Insufficient experience in patients >65 years of age to determine whether geriatric patients respond differently than younger adults.¹

Possible increased incidence of infections and malignancies in geriatric patients; use with caution.¹ (See Infectious Complications and also Malignancies and Lymphoproliferative Disorders under Cautions.)

Common Adverse Effects

Upper respiratory infection, nasopharyngitis, headache, nausea.¹

Interactions for Abatacept

Vaccines

Data not available on the effects of immunization in patients receiving abatacept.¹

Avoid live virus vaccines (e.g., measles virus vaccine live, mumps virus vaccine live, rubella virus vaccine live, poliovirus vaccine live oral [no longer commercially available in US], smallpox vaccine, typhoid vaccine live oral, varicella vaccine live, yellow fever vaccine).¹ No data available on secondary transmission of infection by live virus vaccines in abatacept-treated patients.¹ Since abatacept may interfere with the immune response to antigens, vaccine efficacy may be reduced in patients receiving the drug.¹ (See Vaccination under Cautions and see Pediatric Use under Cautions.)

Specific Drugs and Laboratory Tests

Drug	Interaction	Comments
Biologic antirheumatic drugs (e.g., anakinra)	Insufficient experience to assess safety and efficacy of concomitant use¹	Concomitant use not recommended¹
Corticosteroids	Concomitant use does not alter clearance of abatacept ¹
Methotrexate	Concomitant use does not alter clearance of abatacept ¹
NSAIAs	Concomitant use does not alter clearance of abatacept ¹
Tests for glucose	Maltose contained in abatacept injection may interfere with blood glucose monitoring systems based on glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ) and cause falsely elevated blood glucose results¹	Use only glucose-specific test methods not affected by maltose (e.g., glucose dehydrogenase nicotine adenine dinucleotide [GDH-NAD], glucose oxidase, glucose hexokinase)¹
TNF-blocking agents (adalimumab, certolizumab pegol, etanercept, infliximab)	Increased incidence of potentially serious infections¹	Concomitant use not recommended¹ (See Infectious Complications under Cautions.)

Abatacept Pharmacokinetics

Absorption

Following multiple IV infusions, steady-state serum concentrations reached at 60 days.¹ Systemic accumulation does not appear to occur.¹

Elimination

Half-life

Terminal half-life averages 13.1 days.¹

Special Populations

Age and gender (adjusted for body weight) do not affect clearance.¹

Clearance increases with increasing body weight.¹

Pharmacokinetics not evaluated in patients with hepatic or renal impairment.¹

Stability

Storage

Parenteral

Powder for Injection

2–8°C in the original container; protect from light.¹

Store fully diluted solution at either room temperature or between 2–8°C.¹ Infusion of diluted solution must be completed within 24 hours of reconstitution.¹

Compatibility

For information on systemic interactions resulting from concomitant use, see Interactions.

Parenteral

Solution Compatibility

Compatible
Sodium chloride 0.9%.¹

Drug Compatibility

Information on the physical and/or chemical compatibility with other drugs is not available.¹

ActionsActions

Inhibits T-cell activation by binding to CD80 and CD86, further blocking interaction with CD28.¹ ² ³ ⁴ ⁵

Decreases T-cell proliferation and inhibits production of TNFα, interferon-γ and IL–2.¹

Suppresses inflammation, decreases anti-collagen antibody production, and reduces antigen specific production of interferon-γ.¹

Advice to Patients

Importance of providing patient a copy of the manufacturer's patient information.¹

Importance of patient informing clinician about existing infections prior to initiating therapy.¹ Importance of patients informing clinicians promptly if any signs or symptoms of infection occur during therapy.¹

Advise patients that this preparation contains maltose and may cause falsely elevated glucose readings when blood glucose monitoring systems based on glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ) are used; importance of using glucose-specific test methods not affected by maltose.¹

Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.¹

Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription (e.g., TNF blocking agents, biologic antirheumatic drugs, immunizations) and OTC drugs, as well as any other illnesses (e.g., concomitant or recurrent infections, history of tuberculosis, history of HBV infection, diabetes mellitus).¹

Importance of informing patients of other important precautionary information.¹ (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Abatacept
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Parenteral	For Injection	250 mg	Orencia	Bristol-Myers Squibb

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Orencia 250MG Solution (B-M SQUIBB U.S. (PRIMARY CARE)): 1/$590.99 or 3/$1695.97

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions April 2009. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

1. Bristol-Myers Squibb. Orencia (abatacept) prescribing information. Princeton, NJ; 2008 Apr.

2. Genovese MC, Becker JC, Schiff M et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition. N Engl J Med. 2005; 353:1114-23. [PubMed 16162882]

3. Kremer JM, Westhovens R, Leon M et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med. 2003; 349:1907-15. [PubMed 14614165]

4. Kremer JM, Dougados M, Emery P et al. Treatment of rheumatoid arthritis with the selective costimulatory modulator abatacept: twelve-month results of a phase IIb, double-blind, randomized, placebo-controlled trial. Arthritis Rheum. 2005; 52:2263-71. [PubMed 16052582]

5. Moreland LW, Alten R, Van den Bosch F et al. Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion. Arthritis Rheum. 2002; 46:1470-9. [PubMed 12115176]

6. Bristol-Myers Squibb, Plainsboro, NJ: Personal communication.

7. Ruperto N, Lovell DJ, Quartier P et al. Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial. Lancet. 2008; 372;383-91. [PubMed 18632147]

8. Giannini EH, Ruperto N, Ravelli A et al. Preliminary definition of improvement in juvenile arthritis. Arthritis Rheum. 1997; 40:1202-9. [PubMed 9214419]

More Abatacept resources

Abatacept Side Effects (in more detail)
Abatacept Use in Pregnancy & Breastfeeding
Abatacept Drug Interactions
Abatacept Support Group
5 Reviews for Abatacept - Add your own review/rating

Abatacept MedFacts Consumer Leaflet (Wolters Kluwer)

Abatacept Professional Patient Advice (Wolters Kluwer)

abatacept Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information

Orencia Prescribing Information (FDA)

Orencia Consumer Overview

Compare Abatacept with other medications

Juvenile Idiopathic Arthritis
Psoriatic Arthritis
Rheumatoid Arthritis

Apokyn

Generic Name: apomorphine (Subcutaneous route)

a-poe-MOR-feen

Commonly used brand name(s)

In the U.S.

Apokyn

Available Dosage Forms:

Solution

Therapeutic Class: Antiparkinsonian

Pharmacologic Class: Dopamine Agonist

Uses For Apokyn

Apomorphine is used to treat Parkinson's disease, sometimes referred to as "shaking palsy." By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced .

This medicine is available only with your doctor's prescription .

Before Using Apokyn

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of apomorphine in children with use in other age groups .

Geriatric

Confusion, hallucinations, falls causing bone and joint injuries, heart, lung, or stomach problems may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of apomorphine .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Alosetron

Cisapride

Dolasetron

Dronedarone

Granisetron

Mesoridazine

Ondansetron

Palonosetron

Pimozide

Sparfloxacin

Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alfuzosin

Amiodarone

Amitriptyline

Amoxapine

Arsenic Trioxide

Asenapine

Astemizole

Azithromycin

Chloroquine

Chlorpromazine

Ciprofloxacin

Citalopram

Clarithromycin

Clomipramine

Clozapine

Crizotinib

Dasatinib

Desipramine

Disopyramide

Dofetilide

Droperidol

Entacapone

Erythromycin

Flecainide

Fluconazole

Gatifloxacin

Gemifloxacin

Halofantrine

Haloperidol

Ibutilide

Iloperidone

Imipramine

Lapatinib

Levofloxacin

Lopinavir

Lumefantrine

Mefloquine

Methadone

Moxifloxacin

Nilotinib

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Paliperidone

Pazopanib

Perflutren Lipid Microsphere

Posaconazole

Procainamide

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Quinine

Ranolazine

Salmeterol

Saquinavir

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sorafenib

Sotalol

Sunitinib

Telavancin

Telithromycin

Terfenadine

Tetrabenazine

Toremifene

Trazodone

Trifluoperazine

Vandetanib

Vardenafil

Vemurafenib

Voriconazole

Ziprasidone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of Apokyn

Some medicines given by injection may sometimes be given at home to patients who do not need to be in the hospital. If you are using this medicine at home, make sure you clearly understand and carefully follow your doctor's instructions .

Use this medicine only as directed by your doctor. Do not use more or less of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chance of side effects .

This medicine should be injected just under the skin (i.e., subcutaneously), and not into a vein (i.e., intravenously) .

Your doctor will also prescribe another medicine called an antiemetic to take when you are using apomorphine. Antiemetic medicines help reduce the nausea and vomiting that can occur with apomorphine use .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For parenteral dosage form (injection):
- For treatment of Parkinson's disease:
  - Adults—Your doctor will use a test dose of 0.2 mL and base your starting dose on how your body responds to the test dose .
  - Children—Use and dose must be determined by your doctor .

Missed Dose

Call your doctor or pharmacist for instructions.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Apokyn

When you are using apomorphine, you should avoid drinking alcohol.

Do not take medicines that cause sleepiness while taking apomorphine .

Do not take other medicines unless they have been discussed with your doctor .

If you take too much apomorphine, you may experience more side effects or they may be stronger than usual. You should contact your doctor or have someone take you to an emergency room right away.

Tell your doctor if you are having trouble with drowsiness and sleepiness during the day .

This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Do not get up too quickly from a lying or sitting position. This could cause dizziness and faintness to occur .

Apokyn Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain, discomfort, or pressure

chills

cold sweats

confusion

dizziness, faintness, or light-headedness when getting up from lying or sitting position

falling asleep during activity

mood or mental changes

seeing, hearing, or feeling things that are not there

swelling

twitching, twisting, uncontrolled repetitive movements of tongue, lips, face, arms, or legs

Less common

Arm, back, neck or jaw pain or discomfort

chest tightness or heaviness

fainting

fast or irregular heartbeat

low blood pressure or pulse

nausea

shortness of breath

sweating

unconsciousness

vomiting

Rare

Irregular heartbeat

recurrent fainting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site

blurred vision

dizziness

drowsiness

runny nose

sleepiness

yawning

Rare

Painful or prolonged erection of the penis

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Apokyn side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Apokyn resources

Apokyn Side Effects (in more detail)
Apokyn Use in Pregnancy & Breastfeeding
Apokyn Drug Interactions
Apokyn Support Group
3 Reviews for Apokyn - Add your own review/rating

Apokyn Prescribing Information (FDA)

Apokyn Monograph (AHFS DI)

Apokyn MedFacts Consumer Leaflet (Wolters Kluwer)

Apokyn Consumer Overview

Compare Apokyn with other medications

Parkinson's Disease

Acetaminophen/Diphenhydramine Capsules

Pronunciation: a-seet-a-MIN-oh-fen/dye-fen-HYE-dra-meen
Generic Name: Acetaminophen/Diphenhydramine
Brand Name: Examples include Excedrin PM and Sominex

Acetaminophen/Diphenhydramine Capsules is used for:

Relieving short-term sleeplessness due to minor aches and pains. It may also used for other conditions as determined by your doctor.

Acetaminophen/Diphenhydramine Capsules is an antihistamine and analgesic combination. Diphenhydramine causes drowsiness to help you fall asleep. Acetaminophen works in certain areas of the brain and nervous system to decrease pain.

Do NOT use Acetaminophen/Diphenhydramine Capsules if:

you are allergic to any ingredient in Acetaminophen/Diphenhydramine Capsules

you are taking sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Acetaminophen/Diphenhydramine Capsules:

Some medical conditions may interact with Acetaminophen/Diphenhydramine Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day

if you have a fast, slow, or irregular heartbeat; liver problems (eg, hepatitis); or kidney problems

if you have a history of asthma; lung problems (eg, emphysema); heart problems; high blood pressure; diabetes; heart blood vessel problems; stroke; glaucoma; a blockage of your stomach, bladder, or intestines; ulcers; trouble urinating; an enlarged prostate; seizures; or an overactive thyroid

Some MEDICINES MAY INTERACT with Acetaminophen/Diphenhydramine Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

Furazolidone, MAO inhibitors (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Acetaminophen/Diphenhydramine Capsules may be increased

Anticoagulants (eg, warfarin) because the risk of side effects, such as bleeding, may be increased by Acetaminophen/Diphenhydramine Capsules

Hydantoins (eg, phenytoin) because side effects may be increased by Acetaminophen/Diphenhydramine Capsules

Isoniazid because side effects of Acetaminophen/Diphenhydramine Capsules may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Acetaminophen/Diphenhydramine Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Acetaminophen/Diphenhydramine Capsules:

Use Acetaminophen/Diphenhydramine Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Acetaminophen/Diphenhydramine Capsules may be taken with or without food.

If you miss a dose of Acetaminophen/Diphenhydramine Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Acetaminophen/Diphenhydramine Capsules.

Important safety information:

Acetaminophen/Diphenhydramine Capsules may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Acetaminophen/Diphenhydramine Capsules. Using Acetaminophen/Diphenhydramine Capsules alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Do NOT exceed the recommended dose or take Acetaminophen/Diphenhydramine Capsules for longer than prescribed without checking with your doctor.

If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.

Acetaminophen/Diphenhydramine Capsules may cause liver damage. If you consume 3 or more alcohol-containing drinks every day, ask your doctor if you should take Acetaminophen/Diphenhydramine Capsules or other pain relievers/fever reducers. Alcohol use combined with Acetaminophen/Diphenhydramine Capsules may increase your risk for liver damage.

Acetaminophen/Diphenhydramine Capsules contains acetaminophen. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen. If it does or if you are uncertain, contact your doctor or pharmacist.

Acetaminophen/Diphenhydramine Capsules may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Acetaminophen/Diphenhydramine Capsules. Use a sunscreen or protective clothing if you must be outside for a prolonged period.

If you are scheduled for allergy skin testing, do not take Acetaminophen/Diphenhydramine Capsules for several days before the test because it may decrease your response to the skin tests.

Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Acetaminophen/Diphenhydramine Capsules.

Use Acetaminophen/Diphenhydramine Capsules with caution in the ELDERLY because they may be more sensitive to its effects.

Caution is advised when using Acetaminophen/Diphenhydramine Capsules in CHILDREN because they may be more sensitive to its effects.

PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Acetaminophen/Diphenhydramine Capsules, discuss with your doctor the benefits and risks of using Acetaminophen/Diphenhydramine Capsules during pregnancy. It is unknown if Acetaminophen/Diphenhydramine Capsules is excreted in breast milk. Do not breast-feed while taking Acetaminophen/Diphenhydramine Capsules.

Possible side effects of Acetaminophen/Diphenhydramine Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine or pale stools; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; stomach pain; tremor; trouble sleeping; unusual fatigue; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Acetaminophen/Diphenhydramine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Acetaminophen/Diphenhydramine Capsules:

Store Acetaminophen/Diphenhydramine Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Acetaminophen/Diphenhydramine Capsules out of the reach of children and away from pets.

General information:

If you have any questions about Acetaminophen/Diphenhydramine Capsules, please talk with your doctor, pharmacist, or other health care provider.

Acetaminophen/Diphenhydramine Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Acetaminophen/Diphenhydramine Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Acetaminophen/Diphenhydramine resources

Acetaminophen/Diphenhydramine Side Effects (in more detail)
Acetaminophen/Diphenhydramine Use in Pregnancy & Breastfeeding
Drug Images
Acetaminophen/Diphenhydramine Drug Interactions
Acetaminophen/Diphenhydramine Support Group
13 Reviews for Acetaminophen/Diphenhydramine - Add your own review/rating

Compare Acetaminophen/Diphenhydramine with other medications

Headache
Insomnia
Pain

azatadine

Generic Name: azatadine (a ZAT a deen)

Brand Names: Optimine

What is azatadine?

Azatadine is an antihistamine. Azatadine blocks the effects of the naturally occurring chemical histamine in your body.

Azatadine is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.

Azatadine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about azatadine?

Use caution when driving, operating machinery, or performing other hazardous activities. Azatadine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking azatadine.

Who should not take azatadine?

Do not take azatadine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

glaucoma or increased pressure in the eye;

a stomach ulcer;

an enlarged prostate, bladder problems or difficulty urinating;

an overactive thyroid (hyperthyroidism);

hypertension or any type of heart problems; or

asthma.

You may not be able to take azatadine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Azatadine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take azatadine without first talking to your doctor if you are pregnant. Azatadine passes into breast milk. Infants are especially sensitive to the effects of antihistamines, and serious side effects could occur in a nursing baby. Azatadine is not recommended if you are breast-feeding a baby. Do not take azatadine without first talking to your doctor if you are nursing a baby. If you are over 60 years of age, you may be more likely to experience side effects from azatadine. You may require a lower dose of this medication.

How should I take azatadine?

Take azatadine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Azatadine can be taken with or without food.

Never take more of this medication than is prescribed for you. The maximum amount of azatadine that you should take in 1 day is 2 mg.

Store azatadine at room temperature away from moisture and heat.

See also: Azatadine dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an azatadine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.

What should I avoid while taking azatadine?

Azatadine side effects

Stop taking azatadine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take azatadine and talk to your doctor if you experience

sleepiness, fatigue, or dizziness;

headache;

dry mouth; or

difficulty urinating or an enlarged prostate.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Azatadine Dosing Information

Usual Adult Dose for Allergic Reaction:

1 to 2 mg orally twice a day

Usual Adult Dose for Allergic Rhinitis:

1 to 2 mg orally twice a day

Usual Adult Dose for Urticaria:

1 to 2 mg orally twice a day

Usual Pediatric Dose for Allergic Reaction:

>=12 years: 1 to 2 mg orally twice a day

Usual Pediatric Dose for Allergic Rhinitis:

>=12 years: 1 to 2 mg orally twice a day

Usual Pediatric Dose for Urticaria:

>=12 years: 1 to 2 mg orally twice a day

What other drugs will affect azatadine?

Talk to your pharmacist before taking other over-the-counter cough, cold, allergy, or insomnia medications. These may contain medicines similar to azatadine, which could lead to an overdose of antihistamine.

Before taking this medication, tell your doctor if you are taking any of the following medicines:

anxiety or sleep medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion);

medications for depression such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil); or

any other medications that make you feel drowsy, sleepy, or relaxed.

Drugs other than those listed here may also interact with azatadine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More azatadine resources

Azatadine Side Effects (in more detail)
Azatadine Dosage
Azatadine Use in Pregnancy & Breastfeeding
Azatadine Drug Interactions
Azatadine Support Group
0 Reviews for Azatadine - Add your own review/rating

Compare azatadine with other medications

Allergic Reactions
Hay Fever
Urticaria

Where can I get more information?

Your pharmacist has more information about azatadine written for health professionals that you may read.

See also: azatadine side effects (in more detail)

ACT Restoring Mouthwash Vanilla Mint

Generic Name: fluoride topical (FLOR ide TOP i kal)

Brand Names: ACT Fluoride Rinse, ACT Kids Fluoride Rinse, ACT Restoring Mouthwash Cinnamon, ACT Restoring Mouthwash Mint, ACT Restoring Mouthwash Spearmint, ACT Restoring Mouthwash Vanilla Mint, Control Rx, Denta 5000 Plus, Dentagel, Ethedent, Fluoridex, Fluoridex Daily Defense, Fluoridex Daily Defense Enhanced Whitening, Fluorigard, Fluorinse, Gel-Kam, Gel-Kam Dental Therapy Pak, Gel-Kam Dentinbloc, Gel-Kam Sensitivity Therapy, NaFrinse Daily/Acidulated, NaFrinse Daily/Neutral, Nafrinse Solution, NaFrinse Weekly, Neutracare Gel, Neutragard, Neutragard Advanced, Neutral Sodium Fluoride Rinse, Omnii Gel, Omnii Gel Just For Kids, Oral B Anti-Cavity, Perfect Choice, Perio Med, Phos-Flur, Prevident, Prevident 500 Plus Boost, PreviDent 5000 Booster, Prevident 5000 Dry Mouth, Prevident 5000 Plus, Prevident 5000 Sensitive, Prevident Dental Rinse, SF, SF 5000 Plus, Stop, Thera-Flur-N

What is ACT Restoring Mouthwash Vanilla Mint (fluoride topical)?

Fluoride is a substance that strengthens tooth enamel. This helps to prevent dental cavities.

Fluoride topical is used as a medication to prevent tooth decay in patients that have a low level of fluoride topical in their drinking water. Fluoride topical is also used to prevent tooth decay in patients who undergo radiation of the head and/or neck, which may cause dryness of the mouth and an increased incidence of tooth decay.

Fluoride may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about ACT Restoring Mouthwash Vanilla Mint (fluoride topical)?

Fluoride topical should not be used if the level of fluoride in the drinking water is greater than 0.7 parts per million (ppm).

Before using fluoride topical, tell your dentist and doctor if you are on a low salt or a salt free diet. You may not be able to use fluoride topical, or you may need special tests while you are using it.

Do not eat, drink, or rinse your mouth for 30 minutes after using a fluoride topical. Do not swallow fluoride topical. Spit it out after use. Do not allow a child to swallow fluoride topical or serious overdose symptoms could result.

Overdose symptoms may result if you swallow large amounts of fluoride while using it.

What should I discuss with my healthcare provider before using ACT Restoring Mouthwash Vanilla Mint (fluoride topical)?

Fluoride topical should not be used if the level of fluoride in the drinking water is greater than 0.7 parts per million (ppm).

If you have gum disease, some forms of fluoride topical may be irritating to your gums. Talk to your dentist or doctor if you have bothersome mouth irritation while using fluoride topical.

Talk to your doctor and dentist before using fluoride topical if you are pregnant. Talk to your doctor and dentist before using fluoride topical if you are breast-feeding. The use of fluoride is particularly important in children to protect against tooth decay. The American Dental Association's Council on Dental Therapeutics recommends the use of fluoride by children up to 13 years of age. The American Academy of Pediatrics recommends fluoride supplementation in children until the age of 16 years old. Do not allow a child to swallow fluoride topical or serious overdose symptoms could result.

How should I use ACT Restoring Mouthwash Vanilla Mint (fluoride topical)?

Use this medication exactly as directed on the label, or as it was prescribed by your dentist or doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Fluoride topical should be used immediately after brushing or flossing your teeth. For best results, use the medication just before bedtime, unless your doctor tells you otherwise.

Swish this medication in your mouth without swallowing. Then spit it out.

Do not eat, drink, or rinse your mouth for 30 minutes after using fluoride topical. Store fluoride topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, stomach pain, diarrhea, drooling, numbness or tingling, loss of feeling anywhere in your body, muscle stiffness, or seizure (convulsions).

Overdose symptoms may result if you swallow large amounts of fluoride while using it.

What should I avoid while using ACT Restoring Mouthwash Vanilla Mint (fluoride topical)?

Do not swallow fluoride topical. Spit it out after use.

ACT Restoring Mouthwash Vanilla Mint (fluoride topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor if you have any of the following side effects:

discolored teeth;

weakened tooth enamel; or

any changes in the appearance of your teeth.

Less serious side effects may include:

stomach upset;

headache; or

weakness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ACT Restoring Mouthwash Vanilla Mint (fluoride topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied fluoride. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More ACT Restoring Mouthwash Vanilla Mint resources

ACT Restoring Mouthwash Vanilla Mint Side Effects (in more detail)
ACT Restoring Mouthwash Vanilla Mint Use in Pregnancy & Breastfeeding
0 Reviews for ACT Restoring Mouthwash Vanilla Mint - Add your own review/rating

APF Gel Advanced Consumer (Micromedex) - Includes Dosage Information

EtheDent Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Gel-Kam Rinse MedFacts Consumer Leaflet (Wolters Kluwer)

Phos-Flur Cream MedFacts Consumer Leaflet (Wolters Kluwer)

PreviDent 5000 Sensitive MedFacts Consumer Leaflet (Wolters Kluwer)

Prevident 5000 Booster Prescribing Information (FDA)

Prevident 5000 Dry Mouth Prescribing Information (FDA)

Prevident 5000 Enamel Protect Prescribing Information (FDA)

Prevident 5000 Sensitive Prescribing Information (FDA)

Compare ACT Restoring Mouthwash Vanilla Mint with other medications

Prevention of Dental Caries

Where can I get more information?

Your pharmacist can provide more information about fluoride topical.

See also: ACT Restoring Mouthwash Vanilla Mint side effects (in more detail)

Allantoin/Coal Tar Shampoo

Pronunciation: a-LAN-toyn/kohl tar
Generic Name: Allantoin/Coal Tar
Brand Name: Original Tegrin Medicated

Allantoin/Coal Tar Shampoo is used for:

Relieving itching, scaling, dryness, and flaking of the skin due to dandruff, eczema, psoriasis, and seborrhea. It may also be used for other conditions as determined by your doctor.

Allantoin/Coal Tar Shampoo is a keratolytic. It works by slowing bacterial growth and loosing and softening scales and crust.

Do NOT use Allantoin/Coal Tar Shampoo if:

you are allergic to any ingredient in Allantoin/Coal Tar Shampoo

you have a condition that makes you sensitive to sunlight (eg, lupus, allergy to sunlight)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Allantoin/Coal Tar Shampoo:

Some medical conditions may interact with Allantoin/Coal Tar Shampoo. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are using any other treatment for psoriasis, including ultraviolet radiation or a prescription medicine

Some MEDICINES MAY INTERACT with Allantoin/Coal Tar Shampoo. However, no specific interactions with Allantoin/Coal Tar Shampoo are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Allantoin/Coal Tar Shampoo may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Allantoin/Coal Tar Shampoo:

Use Allantoin/Coal Tar Shampoo as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Wet the scalp and hair. Apply the medicine to the scalp, massage into a lather, and allow it to remain on the scalp for 5 minutes. Rinse thoroughly and repeat.

Wash your hands after using Allantoin/Coal Tar Shampoo.

If you miss a dose of Allantoin/Coal Tar Shampoo, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Allantoin/Coal Tar Shampoo.

Important safety information:

Avoid getting Allantoin/Coal Tar Shampoo in your eyes, nose, and mouth. If you get Allantoin/Coal Tar Shampoo in your eyes, immediately wash them out with cool tap water.

Allantoin/Coal Tar Shampoo may be harmful if swallowed. If you may have taken Allantoin/Coal Tar Shampoo by mouth, contact your local poison control center or emergency room immediately.

Do not use Allantoin/Coal Tar Shampoo on open, raw, inflamed, or infected skin.

Do not use Allantoin/Coal Tar Shampoo in or around the genital area, groin, or rectum unless you doctor tells you otherwise.

Do not use any other medicines or special cleansers on the affected area without first checking with your doctor.

Do not use Allantoin/Coal Tar Shampoo over a large area of your body without first talking to your doctor.

Do not use Allantoin/Coal Tar Shampoo for a prolonged period of time without consulting your doctor.

Allantoin/Coal Tar Shampoo may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Allantoin/Coal Tar Shampoo. Use a sunscreen or protective clothing if you must be outside for a prolonged period.

Allantoin/Coal Tar Shampoo may stain hair, skin, and clothing.

Do not use soap, detergent, or other shampoo on your hair before or after using Allantoin/Coal Tar Shampoo.

Use Allantoin/Coal Tar Shampoo with extreme caution in CHILDREN younger than 2 years of age. Safety and effectiveness in this age group have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Allantoin/Coal Tar Shampoo during pregnancy. It is unknown if Allantoin/Coal Tar Shampoo is excreted in breast milk. If you are or will be breast-feeding while you are using Allantoin/Coal Tar Shampoo, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Allantoin/Coal Tar Shampoo:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Itching, burning, tenderness, or redness; sensitivity to sunlight.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive dryness; irritation.

See also: Allantoin/Coal Tar side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Allantoin/Coal Tar Shampoo:

Store Allantoin/Coal Tar Shampoo at room temperature between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Allantoin/Coal Tar Shampoo out of the reach of children and away from pets.

General information:

If you have any questions about Allantoin/Coal Tar Shampoo, please talk with your doctor, pharmacist, or other health care provider.

Allantoin/Coal Tar Shampoo is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Allantoin/Coal Tar Shampoo. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Allantoin/Coal Tar resources

Allantoin/Coal Tar Side Effects (in more detail)
Allantoin/Coal Tar Use in Pregnancy & Breastfeeding
Allantoin/Coal Tar Support Group
4 Reviews for Allantoin/Coal Tar - Add your own review/rating

Compare Allantoin/Coal Tar with other medications

Dermatitis
Psoriasis
Seborrheic Dermatitis